Claudio Ottoni

Sito web: 
https://orcid.org/0000-0001-8870-1589
https://www.ercfelix.com
Ente di appartenenza: 
Università di Roma Tor Vergata
Dipartimento di afferenza: 
Biologia
Profilo competenze: 

Sono un biologo evoluzionista e la mia attività di ricerca si concentra sull'uso del DNA antico come strumento per ricostruire la storia delle popolazioni umane e animali. Integrando i dati genetici con le prove archeologiche e biomolecolari, il mio lavoro esplora i processi di domesticazione degli animali e l'evoluzione dei microrganismi antichi. Dall'aprile 2021 sono professore associato di Antropologia Molecolare presso il Dipartimento di Biologia dell'Università di Roma Tor Vergata, dove la mia attuale ricerca si concentra sull'addomesticamento del gatto.

Progetti di ricerca: 

1 National Geographic, The Making of a pet

Principal Investigator, 2020-2021

2 ERC CoG, FELIX 

Principal Investigator, 2021-2026

Principali pubblicazioni: 

2025

De Martino, M., De Cupere, B., Rovelli, V., Serventi, P., Mouraud, B., Baldoni, M., Di Corcia, T., Geiger, S., Alhaique, F., Alves, P.C., Buitenhuis, H., Ceccaroni, E., Cerilli, E., De Grossi Mazzorin, J., Detry, C., Dowd, M., Fiore, I., Gourichon, L., Grau-Sologestoa, I., Küchelmann, H.C., Kunst, G.K., McCarthy, M., Miccichè, R., Minniti, C., Moreno, M., Mrđić, N., Onar, V., Oueslati, T., Parrag, M., Pino Uria, B., Romagnoli, G., Rugge, M., Salari, L., Saliari, K., Santos, A.B., Schmölcke, U., Sforzi, A., Soranna, G., Spassov, N., Tagliacozzo, A., Tinè, V., Trixl, S., Vuković, S., Wierer, U., Wilkens, B., Doherty, S., Sykes, N., Frantz, L., Mattucci, F., Caniglia, R., Larson, G., Peters, J., Van Neer, W., Ottoni, C. (2025). "The dispersal of domestic cats from North Africa to Europe around 2000 years ago". Science 390. doi:10.1126/science.adt2642.

Shev, G.T., De Cupere, B., Brozou, A., Fuller, B.T., Mannino, M.A., Peters, J., Van Neer, W., Bouillon, S., Ottoni, C. (2025). "Non-exchangeable hydrogen (δ2H) stable isotope ratios in fauna provide enhanced dietary, isotopic niche and home range reconstruction at Aqaba Castle, Jordan". PLoS One 20:e0328991.

2024

Fiorin, E., Roberts, C.A., Baldoni, M., Connelly, E., Lee, C., Ottoni, C., Cristiani, E. (2024). "First archaeological evidence for ginger consumption as a potential medicinal ingredient in a late medieval leprosarium at St Leonard, Peterborough, England". Sci Rep 14:2452.

2023

Brozou, A., Fuller, B.T., De Cupere, B., Marrast, A., Monchot, H., Peters, J., Van de Vijver, K., Lambert, O., Mannino, M.A., Ottoni, C., Van Neer, W. (2023). "A dietary perspective of cat-human interactions in two medieval harbors in Iran and Oman revealed through stable isotope analysis". Sci Rep 13:1-12.

Jamieson, A., Carmagnini, A., Howard-McCombe, J., Doherty, S., Hirons, A., Dimopoulos, E., Lin, A.T., Allen, R., Anderson-Whymark, H., Barnett, R., Batey, C., Beglane, F., Bowden, W., Bratten, J., De Cupere, B., Drew, E., Foley, N.M., Fowler, T., Fox, A., Geigl, E.M., Gotfredsen, A.B., Grange, T., Griffiths, D., Groß, D., Haruda, A., Hjermind, J., Knapp, Z., Lebrasseur, O., Librado, P., Lyons, L.A., Mainland, I., McDonnell, C., Muñoz-Fuentes, V., Nowak, C., O'Connor, T., Peters, J., Russo, I.R.M., Ryan, H., Sheridan, A., Sinding, M.H.S., Skoglund, P., Swali, P., Symmons, R., Thomas, G., Trolle Jensen, T.Z., Kitchener, A.C., Senn, H., Lawson, D., Driscoll, C., Murphy, W.J., Beaumont, M., Ottoni, C., Sykes, N., Larson, G., Frantz, L. (2023). "Limited historical admixture between European wildcats and domestic cats". Curr Biol 33:4751-4760.e14.

2022

Krajcarz, M., Van Neer, W., Krajcarz, M.T., Popović, D., Baca, M., De Cupere, B., Goffette, Q., Küchelmann, H.C., Gręzak, A., Iwaszczuk, U., Ottoni, C., Van de Vijver, K., Wilczyński, J., Mulczyk, A., Wiejacki, J., Makowiecki, D., Bocherens, H. (2022). "Stable isotopes unveil one millennium of domestic cat paleoecology in Europe". Sci Rep 12:12775.

2021

Cristiani, E., Radini, A., Zupancich, A., Gismondi, A., D'Agostino, A., Ottoni, C., Carra, M., Vukojičić, S., Constantinescu, M., Antonović, D., Price, T.D., Borić, D. (2021). "Wild cereal grain consumption among Early Holocene foragers of the Balkans predates the arrival of agriculture". Elife 10:e72976.

Ottoni, C., Borić, D., Cheronet, O., Sparacello, V., Dori, I., Coppa, A., Antonović, D., Vujević, D., Price, T.D., Pinhasi, R., Cristiani, E. (2021). "Tracking the transition to agriculture in Southern Europe through ancient DNA analysis of dental calculus". Proc Natl Acad Sci U S A 118. doi:10.1073/pnas.2102116118.

Ozga, A.T., Ottoni, C. (2021). "Dental calculus as a proxy for animal microbiomes". Quat Int. doi:10.1016/j.quaint.2021.06.012.

Nava, A., Fiorin, E., Zupancich, A., Carra, M., Ottoni, C., Di Carlo, G., Vozza, I., Brugnoletti, O., Alhaique, F., Cremonesi, R.G., Coppa, A., Bondioli, L., Borić, D., Cristiani, E. (2021). "Multipronged dental analyses reveal dietary differences in last foragers and first farmers at Grotta Continenza, central Italy (15,500-7000 BP)". Sci Rep 11:4261.

2020

Ottoni, C., Van Neer, W. (2020). "The Dispersal of the Domestic Cat: Paleogenetic and Zooarcheological Evidence". Near Eastern Archaeology 83:38-45.

Frémondeau, D., Ottoni, C., Ivanova, S., Marinova, E., Spassov, N., Hristova, L., Konyovska, R., Van Neer, W., Lupianez, N., Maria, G. (2020). "New mtDNA and Isotopic Evidence on Late Pleistocene Cave Bears in the Balkans: the Case-study of Magura Cave, NW Bulgaria". Acta Zoologica Bulgarica 72:461-478.

Gabbianelli, F., Alhaique, F., Romagnoli, G., Brancazi, L., Piermartini, L., Ottoni, C., Valentini, A., Chillemi, G. (2020). "Was the Cinta Senese Pig Already a Luxury Food in the Late Middle Ages? Ancient DNA and Archaeozoological Evidence from Central Italy". Genes 11:85.

2019

Ottoni, C., Guellil, M., Ozga, A.T., Stone, A.C., Kersten, O., Bramanti, B., Porcier, S., Van Neer, W. (2019). "Metagenomic analysis of dental calculus in ancient Egyptian baboons". Sci Rep 9:1-10.

2018

Namouchi, A., Guellil, M., Kersten, O., Hänsch, S., Ottoni, C., Schmid, B.V., Pacciani, E., Quaglia, L., Vermunt, M., Bauer, E.L., Derrick, M., Jensen, A.Ø., Kacki, S., Cohn, S.K., Stenseth, N.C., Bramanti, B. (2018). "Integrative approach using Yersinia pestis genomes to revisit the historical landscape of plague during the Medieval Period". Proc Natl Acad Sci U S A 115:E11790-E11797.

Wrobel, A., Ottoni, C., Leo, J.C., Linke, D. (2018). "pYR4 From a Norwegian Isolate of Yersinia ruckeri Is a Putative Virulence Plasmid Encoding Both a Type IV Pilus and a Type IV Secretion System". Front Cell Infect Microbiol 8:373.

Larmuseau, M.H.D., Ottoni, C. (2018). "Mediterranean Y-chromosome 2.0 – why the Y in the Mediterranean is still relevant in the postgenomic era". Ann Hum Biol 45:20-33.

Wrobel, A., Ottoni, C., Leo, J.C., Gulla, S., Linke, D. (2018). "The repeat structure of two paralogous genes, Yersinia ruckeri invasin (yrInv) and a 'Y. ruckeri invasin-like molecule' (yrIlm) sheds light on the evolution of adhesive capacities of a fish pathogen". J Struct Biol 201:171-183.

2017

Ottoni, C., Van Neer, W., De Cupere, B., Daligault, J., Guimaraes, S., Peters, J., Spassov, N., Prendergast, M.E., Boivin, N., Morales-Muñiz, A., Bălăşescu, A., Becker, C., Benecke, N., Boroneant, A., Buitenhuis, H., Chahoud, J., Crowther, A., Llorente, L., Manaseryan, N., Monchot, H., Onar, V., Osypińska, M., Putelat, O., Quintana Morales, E.M., Studer, J., Wierer, U., Decorte, R., Grange, T., Geigl, E.M. (2017). "The palaeogenetics of cat dispersal in the ancient world". Nature Ecology & Evolution 1:0139.

Primativo, G., Ottoni, C., Biondi, G., Serafino, S., Martínez-Labarga, C., Larmuseau, M.H.D., Scardi, M., Decorte, R., Rickards, O. (2017). "Bight of Benin: a Maternal Perspective of Four Beninese Populations and their Genetic Implications on the American Populations of African Ancestry". Ann Hum Genet 81:78-90.

2016

Thieren, E., Ottoni, C., Popović, D., Van Neer, W. (2016). "Inter- and intraspecific variation in the surface pattern of the dermal bones of two sturgeon species". J Appl Ichthyol 32:609-628.

Ottoni, C., Rasteiro, R., Willet, R., Claeys, J., Talloen, P., Van de Vijver, K., Chikhi, L., Poblome, J., Decorte, R. (2016). "Comparing maternal genetic variation across two millennia reveals the demographic history of an ancient human population in southwest Turkey". R Soc Open Sci 3:150250.

Ivanova, S., Gurova, M., Spassov, N., Hristova, L., Tzankov, N., Popov, V., Marinova, E., Makedonska, J., Smith, V., Ottoni, C., Lewis, M. (2016). "Magura Cave, Bulgaria: A multidisciplinary study of Late Pleistocene human palaeoenvironment in the Balkans". Quat Int 415:86-108.

2015

Larmuseau, M.H.D., Vessi, A., Jobling, M.A., Van Geystelen, A., Primativo, G., Biondi, G., Martínez-Labarga, C., Ottoni, C., Decorte, R., Rickards, O. (2015). "The Paternal Landscape along the Bight of Benin – Testing Regional Representativeness of West-African Population Samples Using Y-Chromosomal Markers". PLoS One 10:e0141510.

2014

Purps, J., Siegert, S., Willuweit, S., Nagy, M., Alves, C., Salazar, R., et al. (2014). "A global analysis of Y-chromosomal haplotype diversity for 23 STR loci". Forensic Sci Int Genet 12:12-23.

2013

Ottoni, C., Flink, L.G., Evin, A., Geörg, C., De Cupere, B., Van Neer, W., Bartosiewicz, L., Linderholm, A., Barnett, R., Peters, J., Decorte, R., Waelkens, M., Vanderheyden, N., Ricaut, F.X., Cakirlar, C., Cevik, O., Hoelzel, A.R., Mashkour, M., Karimlu, A.F.M., Seno, S.S., Daujat, J., Brock, F., Pinhasi, R., Hongo, H., Perez-Enciso, M., Rasmussen, M., Frantz, L., Megens, H.J., Crooijmans, R., Groenen, M., Arbuckle, B., Benecke, N., Vidarsdottir, U.S., Burger, J., Cucchi, T., Dobney, K., Larson, G. (2013). "Pig domestication and human-mediated dispersal in western Eurasia revealed through ancient DNA and geometric morphometrics". Mol Biol Evol 30:824-832.

Linseele, V., Riemer, H., Baeten, J., De Vos, D., Marinova, E., Ottoni, C. (2013). "Species identification of archaeological dung remains: A critical review of potential methods". Environ Archaeol 18:5-17.

2012

Larmuseau, M.H.D., Ottoni, C., Raeymaekers, J.A.M., Vanderheyden, N., Larmuseau, H.F.M., Decorte, R. (2012). "Temporal differentiation across a West-European Y-chromosomal cline: genealogy as a tool in human population genetics". Eur J Hum Genet 20:434-440.

2011

Ottoni, C., Larmuseau, M.H.D., Vanderheyden, N., Martínez-Labarga, C., Primativo, G., Biondi, G., Decorte, R., Rickards, O. (2011). "Deep into the roots of the Libyan Tuareg: a genetic survey of their paternal heritage". Am J Phys Anthropol 145:118-124.

Ottoni, C., Ricaut, F.X., Vanderheyden, N., Brucato, N., Waelkens, M., Decorte, R. (2011). "Mitochondrial analysis of a Byzantine population reveals the differential impact of multiple historical events in South Anatolia". Eur J Hum Genet 19:571-576.

2010

Ottoni, C., Primativo, G., Hooshiar Kashani, B., Achilli, A., Martínez-Labarga, C., Biondi, G., Torroni, A., Rickards, O. (2010). "Mitochondrial haplogroup H1 in north Africa: an early holocene arrival from Iberia". PLoS One 5:e13378.

Predazzi, I.M., Martínez-Labarga, C., Vecchione, L., Mango, R., Ciccacci, C., Amati, F., Ottoni, C., Crawford, M.H., Rickards, O., Romeo, F., Novelli, G. (2010). "Population differences in allele frequencies at the OLR1 locus may suggest geographic disparities in cardiovascular risk events". Ann Hum Biol 37:136-148.

2009

Ottoni, C., Koon, H.E.C., Collins, M.J., Penkman, K.E.H., Rickards, O., Craig, O.E. (2009). "Preservation of ancient DNA in thermally damaged archaeological bone". Naturwissenschaften 96:267-278.

Ottoni, C., Martinez-Labarga, C., Vitelli, L., Scano, G., Fabrini, E., Contini, I., Biondi, G., Rickards, O. (2009). "Human mitochondrial DNA variation in Southern Italy". Ann Hum Biol 36:785-811.

Ottoni, C., Martínez-Labarga, C., Loogväli, E.L., Pennarun, E., Achilli, A., De Angelis, F., Trucchi, E., Contini, I., Biondi, G., Rickards, O. (2009). "First genetic insight into Libyan Tuaregs: a maternal perspective". Ann Hum Genet 73:438-448.

2007

Martinez-Labarga, C., Lelli, R., Tarsi, T., Babalini, C., De Angelis, F., Ottoni, C., Giambra, V., Pepe, G., Azebi, E., Frezza, D., Biondi, G., Rickards, O. (2007). "Polymorphisms of the COL1A2, CYP1A1 and HS1,2 Ig enhancer genes in the Tuaregs from Libya". Ann Hum Biol 34:425-436.

Book Chapters

Ottoni, C., Bekaert, B., Decorte, R. (2017). "DNA degradation: Current knowledge and progress in DNA analysis". In Taphonomy of Human Remains: Forensic Analysis of the Dead and the Depositional Environment. Chichester, UK: John Wiley & Sons, Ltd., pp. 65-80.

Keywords: 
DNA antico, genetica, bioarcheologia, domesticazione animale, metagenomica


Estrazione del DNA, preparazione librerie genomiche, sequenziamento Illumina NGS, analisi bioinformatica dei dati di sequenziamento NGS

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